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Vacatures geplaatst door Radboudumc

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Laatste vacatures

PhD candidate 'Social Health And Reserve in the Dementia patient journey'

Do you want to jumpstart your academic career as a PhD student in a truly international environment? Are you in for an engaging scholarly debate with mentors who are passionate about healthy brain aging? Then Nijmegen is the place to be!

The PhD candidate position is part of an international research project that aims to unravel the interplay between social health and biological and psychological factors on the trajectory from cognitively healthy through MCI to dementia. There will be a specific focus on the bidirectional link of social health and cognition before and after dementia develops, the biological substrate on imaging, and the modifying role of brain and cognitive reserve.

You will be involved in a work package that focuses on mapping the multidimensional trajectories of social health and other predictors and outcomes of cognitive decline across the full patient journey. To that aim, you will conduct several epidemiological studies (coordinated and mega-analyses) using existing, international, longitudinal cohort studies. Next, you will coordinate a cross-national qualitative study to enrich the epidemiological and mechanistic understanding of the role of social health in cognitive decline trajectories.

The SHARED project is an international collaboration with partners from renowned institutes from eight countries across the world. During your three years of training, you will be working in Nijmegen (Nl) and expected to be working a shorter period in one of the partner institutes abroad. The Neuro-epidemiology group of Erasmus Medical Center, Rotterdam is the second Dutch partner in this project and you will collaborate closely with the PhD candidate appointed in Rotterdam.

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23-01-2019 Radboudumc


PhD candidate 'Pre-operative and intra-operative detection of metastatic lymph nodes in prostate cancer patients'

Patients with prostate cancer do not die from the primary tumor, but from (extended) metastatic disease. One of the first steps towards extended metastatic disease is the presence of lymph node metastases, which is an important factor determining the patients' prognosis. With continuously improving opportunities to very selectively treat small numbers of metastatic sites it is of utmost importance to accurately diagnose the first signs of oligometastatic disease and to define its extent and aggression.

Within our department nano-MRI as well as 68Ga/18F-PSMA PET-CT are two unique complementary techniques for diagnosis of nodal disease, even in very small lymph nodes. However, the biggest challenge we currently face is the surgical removal of these nodes, to histopathologically validate our imaging findings, and to provide guidance to treat oligometastatic disease with curative intent.

The main focus of this PhD project will be to combine pre- and intra-operative imaging for the detection of lymph node metastases to improve the gold standard for pre-operative imaging techniques and to improve the surgical outcome in prostate cancer patients who are at risk of having lymph node metastases. For this, a prospective clinical study will be started in patients with prostate cancer who are eligible for surgical lymph node dissection. Pre-operative 68Ga/18F-PSMA PET-CT and nano-MRI will be acquired, and during surgery a gamma probe will be used for exact localization and identification of suspicious lymph nodes.
Tumorous and non-tumorous lymph nodes as determined on 7T MRI images and by histopathology (gold standard) will be retrospectively assessed on the pre-operatively acquired images.

The PhD candidate will have a pivotal role in the project and collaborate with researchers and clinicians from the Prostate MR Expertise Center (PMRC), the radiology and nuclear medicine research groups and the urology department.

Tasks and responsibilities

  • Design and perform the prospective clinical studies as described above;
  • Analyze scientific data;
  • Write scientific publications and present findings at scientific meetings;
  • Work in a team with other scientists and clinicians to plan, discuss, and perform research in a stimulating environment.

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22-01-2019 Radboudumc


PhD candidate 'Injectable biomaterials made of cell-penetrating gelatin and mesoporous bioglass nanoparticles for treatment of bone infection'

At the Department of Dentistry (research group Regenerative Biomaterials, Radboudumc, Nijmegen, The Netherlands), one four-year PhD position is available focusing on the development of an injectable and antibiotic-free colloidal gel based on gelatin and mesoporous bioglass nanoparticles for minimally invasive treatment of infected bone.

Osteomyelitis is an infection of the bone which may cause severe bone loss. It is increasingly recognized that bacteria can survive within host cells such as macrophages and osteoblasts during osteomyelitis and escape from most antibiotics which usually have a limited capacity to kill intracellular bacteria. Therefore, novel nanostructured bone-substituting biomaterials are urgently required to overcome these challenges by targeting intracellular bacteria and allowing for minimally invasive clinical application. To this end, the well-recognized osteoconductive and antibacterial properties of bioglasses offer unique opportunities for the development of the next generation of antibacterial bone substitutes.

Tasks and responsibilities

  • Synthesize mesoporous bioglass nanoparticles (MBN) and characterize their osteogenic and antibacterial properties;
  • Surface modify the developed nanoparticles for internalization by cells.
  • Construct colloidal gels based the developed MBNs and gelatin nanospheres and characterize their mechanical, injectable properties;
  • Establish a rat model for experimental implant-associated osteomyelitis and evaluate the treatment efficacy of the developed materials;
  • Supervise MSc and BSc students and disseminate the obtained knowledge by scientific publications and presentations at (inter)national conferences, with the ultimate aim to finalize and publicly defend a PhD-thesis.

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22-01-2019 Radboudumc


PhD candidate 'Proactive en Integrale zorg voor Parkinson (PRIME-PD)'

Project 'Proactive en Integrale zorg voor Parkinson (PRIME-PD)'
Met bijzondere steun van een Engelse goede doelen stichting krijgt het Expertisecentrum de mogelijkheid om in 4 jaar tijd de 'gedroomde integrale zorg' te realiseren voor 2.500 patiënten met Parkinson in de regio Nijmegen en omstreken. Daarnaast krijgt het expertisecentrum de mogelijkheid om deze zorg te evalueren en de kennis te delen met anderen. Het PRIME-PD project is gestart per 1 november 2018. Naast de implementatie en evaluatie in Nederland zal er ook een implementatie en evaluatie in Engeland plaatsvinden.

De PhD candidate zal onderzoek doen binnen de PRIME-PD study. De interventie in de PRIME-PD studie bestaat uit vier onderdelen:

  1. Verbeteren van samenwerking tussen academische zorgverleners en perifere zorgverleners in de eigen regio van een patiënt;
  2. Inzetten van extra Parkinsonverpleegkundigen als 'case managers' voor patiënten;
  3. Gebruiken van nieuwe technologie om mensen zoveel mogelijk thuis te kunnen begeleiden;
  4. Ondersteunen van patiënten en professionals met goede informatie.

De PhD candidate heeft een belangrijke rol in de methodologische opzet en evaluatie van de interventie, waarbij onderzoek naar de kosten-effectiviteit van de interventie centraal staat.

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22-01-2019 Radboudumc


PhD candidate 'Injectable biomaterials made of cell-penetrating gelatin and mesoporous bioglass nanoparticles for treatment of bone infection'

At the Department of Dentistry (research group Regenerative Biomaterials, Radboudumc, Nijmegen, The Netherlands), one four-year PhD position is available focusing on the development of an injectable and antibiotic-free colloidal gel based on gelatin and mesoporous bioglass nanoparticles for minimally invasive treatment of infected bone.

Osteomyelitis is an infection of the bone which may cause severe bone loss. It is increasingly recognized that bacteria can survive within host cells such as macrophages and osteoblasts during osteomyelitis and escape from most antibiotics which usually have a limited capacity to kill intracellular bacteria. Therefore, novel nanostructured bone-substituting biomaterials are urgently required to overcome these challenges by targeting intracellular bacteria and allowing for minimally invasive clinical application. To this end, the well-recognized osteoconductive and antibacterial properties of bioglasses offer unique opportunities for the development of the next generation of antibacterial bone substitutes.

Tasks and responsibilities

  • Synthesize mesoporous bioglass nanoparticles (MBN) and characterize their osteogenic and antibacterial properties;
  • Surface modify the developed nanoparticles for internalization by cells.
  • Construct colloidal gels based the developed MBNs and gelatin nanospheres and characterize their mechanical, injectable properties;
  • Establish a rat model for experimental implant-associated osteomyelitis and evaluate the treatment efficacy of the developed materials;
  • Supervise MSc and BSc students and disseminate the obtained knowledge by scientific publications and presentations at (inter)national conferences, with the ultimate aim to finalize and publicly defend a PhD-thesis.

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22-01-2019 Radboudumc