Vacatures geplaatst door Erasmus MC

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Laatste vacatures

(Senior) adviseur Europese financiering onderzoek

Als adviseur ben je betrokken bij het vroegtijdig signaleren en creëren van kansen voor financiering van onderzoek en innovatie door de Europese Commissie. Je adviseert onderzoekers, van hoogleraren tot postdocs, bij het voorbereiden van projectaanvragen voor Horizon Europe. Met name Marie Curie programma en grote samenwerkingsprojecten. Verder ben je bekend met relevante andere Europese programma's in dit veld zoals ERC, COST en relevante Europese partnerschappen voor Health. Bijvoorbeeld IHI en EJPRD.

Naast advisering en het nakijken van concept aanvragen, verzorg je met je collega's in het EU team voorlichtingsbijeenkomsten, trainingen en workshops. En draag je zorg voor het vroegtijdig en proactief informeren van onze staf. Samen met de collega's van RDO draag je bij aan de activiteiten die door RDO worden georganiseerd voor interne en externe belanghebbenden.

Je bent onderdeel van Team EU en rapporteert aan de coördinator van dit team.

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01-12-2022 Erasmus MC
PhD student: evaluation of radioactive anticancer treatments for pediatric brain tumors

We are looking for a highly motivated PhD student to work on a project focusing on development and optimization of radioactive anticancer treatment (radiopharmaceutical therapy; RPT) for children with brain tumors. This multidisciplinary project brings together expertise from the fields of nuclear medicine, molecular biology, cell biology and pathology.

RPT is a form of internal radiation therapy, which is induced by systemic or local administration of radiolabeled molecules designed to specifically target tumor cells. RPT is an upcoming novel treatment strategy that has not yet been widely studied for use in patients with brain tumors, despite remarkable success (up to complete responses) in adult cancer patients suffering from neuro-endocrine abdominal tumors. Considering the lack of effective treatment options currently available for children with brain tumors, the goal of this project is to determine through preclinical research which whether RPT also has potential, and in that case, which type of RPT is most potent for the treatment of different types of pediatric brain tumors.

In this translational project, you will be trained in using various laboratory techniques including cell culture, (fluorescent) microscopy, autoradiography, histology and different molecular biological techniques. Additionally, animal work is included which you will perform in collaboration with experienced biotechnicians. At the end of the project, you will have contributed to an overview of possible RPTs for pediatric brain tumors that shall be further evaluated in clinical studies.

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29-11-2022 Erasmus MC
PhD Building an advanced liver organ-on-chip model for metastatic research

Liver metastasis is a lethal state for multiple cancer types, and, to date, no cure is available against it. To develop effective therapies, the biological processes underlying the infiltration of cancer cells in the liver to possibly establish metastases must be elucidated. However, the lack of accurate models of the liver anatomy has been a limiting factor to determine which parameters direct the fate of circulating tumour cells (CTC) in the liver. In this project, we aim at identifying which factors are essential in this process, and more specifically, how CTCs trigger a cascade of events in the liver sinusoid favouring metastases. To this end, we will build an advanced human liver sinusoid model, in the form of an organ-on-a-chip (OoC) platform, that incorporates all essential structural, cellular, and functional features of this organ.

This project is a joined endeavour of Erasmus MC and University of Twente allying complementary expertise. The project is funded by NWO. At both institutions a PhD student will be working on the various aspects of the project. At Erasmus MC, we will focus on the liver metastasis biology using high-end molecular analyses while UTwente will be focus on the engineering aspects and the development of the OoC model. The project has shared and parallel tasks that require a close partnership between the PhD students. Joint meetings will be organized on a regular basis between the two institutions.

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17-11-2022 Erasmus MC
PhD or Postdoctoral Research position on gene therapy for lysosomal storage diseases

The laboratory of Molecular Stem Cell Biology1 at the Center for Lysosomal and Metabolic Diseases2, Departments of Clinical Genetics3 and Pediatrics4 of the Erasmus University Medical Center in Rotterdam, The Netherlands, embedded within the research school MGC (Medical Genetics Centre South West Netherlands and the Erasmus MC Graduate school5,6, is searching for a highly motivated candidate to join our group to develop lentiviral gene therapy for lysosomal storage diseases and to study the molecular mechanisms involved.

Lysosomal storage diseases are a group of ~50 genetic diseases in which one of the lysosomal enzymes responsible for degradation of macromolecules is defective. This results in accumulation of substrates in lysosomes, lysosomal pathology, and eventually cell death. Patients with a lysosomal storage disease have symptoms in multiple tissues and organs including the central nervous system, muscle, cartilage, bone, and visceral organs. We have developed hematopoietic stem cell-mediated lentiviral gene therapy for lysosomal storage diseases in animal models. We are now optimizing this therapy in preparation for a clinical trial and we are investigating the molecular mechanisms by which pathology is restored, with a focus on the central nervous system and passage of the blood-brain barrier.

We use a variety of techniques in the field of molecular biology, biochemistry, cell biology and pathology, including lentiviral gene transduction, bone marrow transplantations, immunofluorescent analysis, functional analysis of mobility and cognition, and genome-wide expression analysis including quantitative proteomic analysis. Our research has strong links with the clinic, in which patients are treated and assessed. We collaborate with Leiden University Medical Center and with various national and international partners and are member of the European Reference Networks EURO-NMD and metabERN.

  1. https://www.erasmusmc.nl/en/sophia/research/groups/molecular-stem-cell-biology-of-lysosomal-storage-diseases
  2. https://www.erasmusmc.nl/en/sophia/research/group/lysosomal-and-metabolic-diseases-clinical-research
  3. https://www.erasmusmc.nl/research/departments/clinical-genetics
  4. https://www.erasmusmc.nl/en/sophia/patient-care
  5. http://www.medgencentre.com/
  6. https://www.eur.nl/en/erasmusmc/graduate-school

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16-11-2022 Erasmus MC
PhD or Postdoctoral Research position on skeletal muscle on a chip for disease modeling and therapy testing

The laboratory of Molecular Stem Cell Biology1 at the Center for Lysosomal and Metabolic Diseases2, Departments of Clinical Genetics3 and Pediatrics4 of the Erasmus University Medical Center in Rotterdam, The Netherlands, embedded within the research school MGC (Medical Genetics Centre South West Netherlands and the Erasmus MC Graduate school5,6, is searching for a highly motivated candidate to join our group to develop lentiviral gene therapy for lysosomal storage diseases and to study the molecular mechanisms involved.

Lysosomal storage diseases are a group of ~50 genetic diseases in which one of the lysosomal enzymes responsible for degradation of macromolecules is defective. This results in accumulation of substrates in lysosomes, lysosomal pathology, and eventually cell death. Patients with a lysosomal storage disease have symptoms in multiple tissues and organs including the central nervous system, muscle, cartilage, bone, and visceral organs. We have generated iPSC-based cell models from patients with lysosomal storage diseases, and we are recapitulating pathology in vitro. These models are used to study the mechanisms by which enzyme deficiency leads to pathology, and for developing treatment options based on personalized medicine. In particular, we developed 3D-tissue engineered skeletal muscle on a chip and an innovative platform to measure contractile force in collaboration with the company Optics11.

We use a variety of techniques in the field of tissue engineering, molecular biology, biochemistry, cell biology and pathology, including cellular reprogramming to iPSCs, gene editing using CRISPR/Cas9, immunofluorescent and electron microscopy analysis, and genome-wide expression analysis including RNAseq and quantitative proteomics. Our research has strong links with the clinic, in which patients are treated and assessed. We collaborate with various national and international partners and are member of the European Reference Networks EURO-NMD and metabERN.

  1. https://www.erasmusmc.nl/en/sophia/research/groups/molecular-stem-cell-biology-of-lysosomal-storage-diseases
  2. https://www.erasmusmc.nl/en/sophia/research/group/lysosomal-and-metabolic-diseases-clinical-research
  3. https://www.erasmusmc.nl/research/departments/clinical-genetics
  4. https://www.erasmusmc.nl/en/sophia/patient-care
  5. http://www.medgencentre.com/
  6. https://www.eur.nl/en/erasmusmc/graduate-school

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16-11-2022 Erasmus MC